Getting started with VALCHLOR

What Is VALCHLOR?

VALCHLOR is made specifically to help treat Stage IA/IB MF-CTCL. It is the first and only FDA-approved gel form of mechlorethamine for patients with Stage IA/IB MF-CTCL who have already used another skin treatment.

How VALCHLOR Works

VALCHLOR is a topical anti-cancer treatment that is formulated to treat early-stage MF-CTCL that fits into your daily routine and:

Treats MF-CTCL by destroying rapidly growing T-cells
Is a gel that can be applied topically, at home once a day
Does not absorb into the bloodstream

Storage note: Refrigeration is required. Please refer to the full handling and storage instructions provided with your prescription.

Clinical Study of VALCHLOR

VALCHLOR was studied in the largest controlled clinical study of people with early-stage (IA/IB) MF-CTCL.

In a 12-month study of 260 people, 119 used VALCHLOR compared with 123 patients who received a different treatment. Doctors followed a few key skin patches over the 12 months to see if they shrunk or disappeared.

Patient responses were captured as either Partial Response (patches got smaller) or Complete Response (patches disappeared).

In the study, 60% of patients using VALCHLOR had their skin lesions shrink by at least half, compared with 48% of patients using another treatment.

What Side Effects Do I Need to Know?

VALCHLOR can cause serious side effects including risk of secondary exposure to VALCHLOR, inflammation of your skin (dermatitis), and increased risk of certain types of skin cancers.

About Skin Irritation (Dermatitis)

VALCHLOR, like other topical skin treatments, may cause side effects. The most common side effect while using VALCHLOR is dermatitis, (inflammation of the skin). If you see or feel any of the following symptoms, make sure to tell your doctor, nurse, or care team immediately:

Redness or swelling
Itching or blisters
Ulcers or open sores
Signs of skin infection
Darkening of areas of your skin

Your doctor may adjust the frequency of VALCHLOR application if skin reactions occur.

To minimize the risk of serious skin irritation, follow these instructions:

Do NOT apply VALCHLOR to your face, genital area, anus, or within skin folds, as there is a high risk for skin irritation in these areas
Apply only to the areas directed by your doctor
Follow your doctor's or nurse's instructions regarding application frequency and technique

Get medical help right away if VALCHLOR gets in your eyes, mouth, or nose.

This website is intended for informational purposes only and does not replace the guidance of your doctor. Always follow your doctor's instructions and refer to the full Prescribing Information and Patient Instructions for Use.

Learn how to use VALCHLOR

Learn about VALCHLOR Support^®

What is VALCHLOR® used for?

VALCHLOR is a prescription medicine used on the skin (topical) to treat people with Stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma who have received previous skin treatment. It is not known if VALCHLOR is safe and effective in children.

Important Safety Information

What is the most important information I should know about VALCHLOR?

VALCHLOR is for use on skin only. Keep VALCHLOR away from your eyes, mouth, and nose.

If VALCHLOR gets in your eyes it can cause eye pain, burning, swelling, redness, sensitivity to light, and blurred vision. It may also cause blindness and permanent injury to your eyes.
If VALCHLOR gets in your mouth or nose it can cause pain, redness, and ulcers.

If VALCHLOR gets in your eyes, rinse your eyes right away for at least 15 minutes with a large amount of water, normal saline, or an eye wash solution.

Get medical help right away if VALCHLOR gets in your eyes, mouth, or nose. Talk with your healthcare provider before using VALCHLOR about how to get medical help.

When should I not use VALCHLOR?

Do not use VALCHLOR if you are severely allergic to mechlorethamine. Tell your healthcare provider if you have had an allergic reaction to mechlorethamine.

What should I tell my healthcare provider?

Before using VALCHLOR, tell your healthcare provider about all your medical conditions, including if you:

are pregnant or plan to become pregnant. VALCHLOR may harm your unborn baby. Avoid becoming pregnant during treatment with VALCHLOR. Tell your healthcare provider right away if you think you are or may become pregnant during treatment with VALCHLOR.
- Females who are able to become pregnant should use a barrier method of birth control, such as a male condom or spermicide, during treatment with VALCHLOR.
- Males with female partners who are able to become pregnant should use a barrier method of birth control, such as a male condom or spermicide, during treatment with VALCHLOR.
are breastfeeding or plan to breastfeed. It is not known if VALCHLOR passes into your breast milk. Do not breastfeed during treatment with VALCHLOR.
Tell your healthcare provider about all the medicines you take including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What should I avoid while using VALCHLOR?

VALCHLOR is flammable. Avoid fire, flame, and smoking until VALCHLOR has dried.

What are the possible side effects of VALCHLOR?

See "What is the most important information I should know about VALCHLOR?"

VALCHLOR can cause serious side effects, including:

Risk of secondary exposure to VALCHLOR. You may have a risk of inflammation of your skin (dermatitis), injury to your eyes, mouth, or nose, and certain types of cancers. Caregivers who accidentally come into contact with VALCHLOR must wash the affected area thoroughly with soap and water right away for at least 15 minutes and remove any contaminated clothing.
Get medical help right away if VALCHLOR gets in your eyes, mouth, or nose.
Inflammation of your skin (dermatitis) is common with VALCHLOR and may sometimes be severe. Your risk for dermatitis is increased if VALCHLOR is applied to your face, genital area, anus, or skin folds. Tell your healthcare provider if you develop skin reactions such as redness, swelling, itching, blisters, ulcers, and skin infections.
Increased risk of certain types of skin cancers. Certain types of skin cancer can develop on areas of your skin that are treated with VALCHLOR and areas of your skin that are not treated with VALCHLOR. Your healthcare provider will check your skin for skin cancers during and after your treatment with VALCHLOR. Tell your healthcare provider if you get any new skin lesions.

The most common side effects of VALCHLOR include: redness, swelling, itching, skin ulcers or blisters, skin infection, and darkening of areas of your skin.

VALCHLOR may cause fertility problems in females and males. This could affect the ability to become pregnant. Talk to your healthcare provider if this is a concern for you.

These are not all of the possible side effects of VALCHLOR. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Keep VALCHLOR and all medicines out of the reach of children.

Please see the full Prescribing Information and Medication Guide for VALCHLOR.