Getting started on VALCHLOR

What to expect

The VALCHLOR prescription process may be different from what you’ve experienced with other prescription medicines.

When your doctor writes a VALCHLOR prescription for you, the two of you will fill out and sign a form that authorizes a specialty pharmacy to fill your prescription and ship VALCHLOR directly to your home. A nurse from the specialty pharmacy will call you to arrange delivery and answer questions you may have about your prescription. Please note that VALCHLOR is not available at your local pharmacy.

VALCHLOR Support provides a range of services to help you start and stay on therapy, including financial assistance for eligible patients. In addition, a VALCHLOR Support representative is available by phone to answer your questions and arrange refills if your doctor orders them.


  • If you are privately insured, VALCHLOR is covered by most health plans*
    • If eligible, you will pay no more than $10 per prescription fill in out-of-pocket co-pay costs for VALCHLOR
    • Offer not valid if your prescription is paid for by any federal or state subsidized healthcare program that covers prescription drugs, including Medicare (Medicare Part D prescription drug benefit), Medicaid, Medigap, VA/DoD (Tricare), Indian Health Service, or similar federal or state programs
  • If you don’t have a prescription plan, you may be eligible for a patient assistance program
  • If your insurance coverage is limited, alternative funding resources may be available


The specialty pharmacy sends VALCHLOR to you under refrigerated conditions. Once you receive your VALCHLOR, please follow these instructions1:

  • Store VALCHLOR in the refrigerator between 36°F and 46°F (2°C and 8°C)
  • Keep VALCHLOR away from food in the refrigerator
  • With clean hands, place VALCHLOR in the box it came in and return it to the refrigerator right after each use
  • Talk with your pharmacist before you use VALCHLOR that has been outside of the refrigerator for more than 1 hour in a day
  • Safely throw away any VALCHLOR that is not used within 90 days. Unused VALCHLOR, empty tubes, and used disposable nitrile gloves should be safely thrown away in household trash
  • Keep VALCHLOR and all medicines out of the reach of children

If you have any questions about your VALCHLOR prescription, talk to your doctor.

*Formulary status is subject to change. Some plans may require prior authorization.
The VALCHLOR co-pay program is only available for residents of the US and Puerto Rico who are 18 or older and have commercial health insurance with co-pay/co-insurance exceeding $10 per prescription fill. Patients ineligible for the VALCHLOR co-pay program include those enrolled in Medicare, Medicaid, VA/DoD (Tricare), the Indian Health Service, or any other federal- or state-funded healthcare program, or where prohibited by law. The VALCHLOR co-pay program is not prescription drug coverage or insurance. Helsinn reserves the right to terminate or modify this program at any time or without notice. Other terms and conditions apply.

  • For questions about your prescription, or to arrange your shipment of VALCHLOR, please call 1-855-4-VALCHLOR (1-855-482-5245). VALCHLOR Support representatives are available to help you Monday through Friday from 8 am to 8 pm Eastern Standard Time.


VALCHLOR® (mechlorethamine) gel is for use on skin only. Do not get VALCHLOR near or in your eyes, mouth, or nose as it can cause pain, redness, swelling, burning, and ulcers. It can also cause sensitivity to light, blurred vision, and may also cause blindness or permanent eye injury. If VALCHLOR gets in your eyes, rinse your eyes right away for at least 15 minutes with a large amount of water, normal saline, or an eyewash solution. If it gets in your nose or mouth, rinse the affected area right away for at least 15 minutes with a large amount of water. Get medical help right away.

Do not use VALCHLOR if you are severely allergic to mechlorethamine. Tell your healthcare provider if you have had an allergic reaction to mechlorethamine.

Before using VALCHLOR, tell your healthcare provider about all your medical conditions. In addition, if you are pregnant, planning a pregnancy, or breastfeeding:

VALCHLOR is flammable. Avoid fire, flame, and smoking until VALCHLOR has dried.


Risk of secondary exposure to VALCHLOR for caregivers who accidentally come into contact with VALCHLOR may include risk of skin inflammation (dermatitis); injury to eyes, mouth, or nose; and certain types of cancer. If accidental contact occurs, wash the affected area with soap and water right away for at least 15 minutes and remove any contaminated clothing. Get medical help right away if VALCHLOR gets in your eyes, mouth, or nose.

Skin inflammation (dermatitis) is common with VALCHLOR and may sometimes be severe. Risk for dermatitis is increased if VALCHLOR is applied to your face, genital area, anus, or skin folds. Tell your healthcare provider if you develop skin reactions such as redness, swelling, itching, blisters, ulcers, and skin infections.

Increased risk of certain types of skin cancers. Certain types of skin cancer can develop on treated and non-treated areas with VALCHLOR. Your healthcare provider will check your skin for skin cancers during and after treatment. Tell your healthcare provider if you get any new skin lesions.

Most common side effects include redness, swelling, itching, skin ulcers or blisters, skin infection, and darkening of areas of your skin.

These are not all the possible side effects of VALCHLOR. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

Keep VALCHLOR and all medicines out of the reach of children.


When applying VALCHLOR, caregivers must wear disposable nitrile gloves, which should be safely thrown away in the household trash. Wash hands with soap and water after touching or applying VALCHLOR. Apply right away or within 30 minutes once taken out of the refrigerator. Refrigerate VALCHLOR right after each use. Apply a thin layer to completely dry skin at least 4 hours before or 30 minutes after showering or washing. Let treated area dry for 5 to 10 minutes after applying VALCHLOR before covering with clothing. Moisturizers may be applied to the treated areas 2 hours before or 2 hours after applying VALCHLOR. Do not use airtight or watertight bandages on areas treated with VALCHLOR.

Please see full Prescribing Information and Medication Guide for VALCHLOR.